The importance and role of animal research and testing

Postgraduate Medicine ; Stewart A. A turning point in cancer research: Sequencing the human genome.

Animal rights vs medical research

Is alcohol hepatotoxic in the baboon? Science editor Philip Abelson has asked, "Are humans to be regarded as behaving biochemically like huge, obese, inbred, cancer-prone rodents? Aping Science. Beeson PB. Data from animal studies is essential before new therapeutic techniques and surgical procedures can be tested on human patients. Beeson and Good have recently emphasized that they do not oppose animal experimentation, and they consider it important to medical progress. Reduction This principle entails that when you perform an animal experiment, you should always use the lowest possible number of animals that will still give you a scientifically and statistically relevant result. Replacement This principle means that - wherever possible - an animal experiment must always be replaced by an alternative that does not require animals. Progress in Neuropsychopharmacology Biology and Psychiatry ; Information from this sort of work can then be applied to higher animals and humans. Cultivation of the Lansing strain of poliomyelitis virus in cultures of various human embryonic tissue. Cell proliferation in carcinogenesis. The lethal dose 50 LD50 , which determines how much of a drug, chemical, or household product is needed to kill 50 percent of a group of test animals, requires 60 to animals usually rats and mice , most of whom endure great suffering. Especially for toxicological research quite a number of valid alternatives have been developed. Barber B.

Nevertheless, the public continues to endorse vivisection, primarily because many people believe that animal experimentation has been vital for most medical advances. Our researchers are strong supporters of animal welfare and view their work with animals in biomedical research as a privilege.

pro animal testing articles

Zbinden G, Flury-Roversi M. The production of monoclonal antibodies: Are animals still needed?

The importance and role of animal research and testing

Cotton P. Kappa-opioids produce significantly greater analgesia in women than in men. Nuclear fallout, low birthweight, and immune deficiency. Alternative methods Animal experiments can be replaced with alternative methods see module Alternative Methods in a variety of areas. Preston R. The Lancet ; Such massive dosing itself can result in cancers, irrespective of a compound's actual carcinogenicity at typical human exposure levels. For example, a mathematical model has indicated that there are two distinct types of breast cancer - one very malignant, the other much less so - that look alike under the microscope.

So depending on the question you need to answer these more complex tissue culture models are a valid alternative to the use of animals.

The fact that some rats developed cancers did not and cannot clarify whether or not saccharin causes cancer in humans. In vitro methods and computer modelling play an important part complementing data from animal models.

How are animals used in research

Modern surgical techniques including hip replacement surgery, kidney transplants, heart transplants and blood transfusions were all perfected in animals. Coley WB. Vivisection is lucrative. In , no testing of household products was carried out using animals in the UK. Psychological research and the rights of animals: Disagreement with Miller [letter]. San Francisco, HarperCollins, , pp Cultivation of the Lansing strain of poliomyelitis virus in cultures of various human embryonic tissue. Problems - applications - future prospects. Northrup E. Significance of the LD50 test for the toxicological evaluation of chemical substances. Baltimore, William and Wilkins, A live-virus AIDS vaccine? It was later found that male rats possess a protein in greater quantity than female rats and lacking in humans that interacted with saccharin to form irritating crystals in the male rats' bladders that caused cancer.
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Why animal research is essential